Immunological mechanisms in atherosclerosis
نویسندگان
چکیده
منابع مشابه
Immunological aspects of atherosclerosis.
Atherosclerosis is a degenerative inflammatory disease of the vascular wall, which is characterized by the formation of atherosclerotic plaques that contain lipids, activated smooth muscle cells, immune cells, foam cells, a necrotic core and calcified sites. In atherosclerosis pathology, monocytes and macrophages play the most important role by accumulating redundant LDL particles in their oxid...
متن کاملImmunological aspects of atherosclerosis.
Cardiovascular disease is the leading cause of death in several countries. The underlying process is atherosclerosis, a slowly progressing chronic disorder that can lead to intravascular thrombosis. There is overwhelming evidence for the underlying importance of our immune system in atherosclerosis. Monocytes, which comprise part of the innate immune system, can be recruited to inflamed endothe...
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متن کاملImmune mechanisms in atherosclerosis.
To summarize, it is possible that T cell activation in the plaque has four different effects: a direct inhibition of smooth muscle proliferation mediated by IFN-gamma, an indirect stimulation of smooth muscle proliferation via IFN-induced macrophage activation, an induction of responsiveness to PDGF by induction of PDGF receptor expression, and finally, an up-regulation of HDL receptors. The ne...
متن کاملInflammatory mechanisms in atherosclerosis.
Throughout the last two decades inflammation has been recognized as the central mechanism underlying atherogenesis. A multitude of basic science work demonstrates the pivotal role of inflammatory processes during every step of atherosclerotic plaque formation: From initiation via propagation to complication. This review describes some of the key mechanisms involved with a particular focus on th...
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ژورنال
عنوان ژورنال: Journal of Internal Medicine
سال: 1995
ISSN: 0954-6820,1365-2796
DOI: 10.1111/j.1365-2796.1995.tb01229.x